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🧪 Downstream Purification & Chromatography

Purification of biopharmaceuticals from cell culture broth to a ready-to-use substance.

11 simulations60 fps real-time0 install steps
3D Protein A Affinity CaptureNewA rotatable packed resin bed rendered in real WebGL — hundreds of Protein A beads capture… Hydrophobic Interaction Chromatography (2D): Salting-Out Elution TimelineNew📱2D side-view HIC column: raise the ammonium-sulfate loading concentration to bind product… Hydrophobic Interaction Chromatography: Salting-Out PurificationNew📱Interactive 3D salting-out chromatography column: raise the ammonium-sulfate concentration… Protein A Affinity Capture ChromatographyNew📱This simulation illustrates the process of affinity capture chromatography using Protein A… Ion-Exchange Polishing ChromatographyNew📱This simulation explains the ion-exchange polishing chromatography technique used to remove… Viral Filtration & Clearance ValidationNew📱This simulation demonstrates the process of nanofiltration for removing or inactivating… Tangential Flow Filtration (UF/DF)New📱This simulation shows the tangential flow filtration (TFF) process for concentrating and… Continuous Chromatography (Multi-Column)New📱This simulation covers continuous multi-column chromatography (MCSGP) for downstream… Host Cell Protein (HCP) Clearance ELISANew📱Quantitative determination of residual host cell proteins in a purified product using the… Endotoxin Removal & LAL TestingNew📱Removal of endotoxins and quality control through LAL testing to ensure the safety of a… Chromatography Resin Lifetime & Reuse CyclesNew📱Simulation of chromatographic resin degradation over reuse cycles to optimize its lifespan…
About the category

Downstream Purification & Chromatography

Purification of biopharmaceuticals from cell culture broth to a ready-to-use substance.

Three.js · WebGL 60 FPS CC BY 4.0
Quick facts
11interactive simulations in this category
⚡runs at 60 FPS in any modern browser
🌐English, Ukrainian, Polish, Spanish, German, Japanese, Italian, Portuguese (Brazil), French, Arabic, Dutch, Chinese, Korean, Hindi, Turkish, Vietnamese, Russian, Indonesian, Persian, Bengali, Thai, Filipino, Swahili, Urdu, Malay, Tamil, Hebrew, Greek, Punjabi, Amharic, Burmese, Khmer, Georgian, Nepali, Mongolian, Armenian, Sinhala, Lao, Czech, Romanian, Hungarian, Bulgarian, Swedish, Danish, Finnish, Norwegian, Slovak, Croatian, Serbian, Slovenian, Lithuanian, Latvian, Estonian, Icelandic, Albanian, Macedonian, Bosnian, and Maltese
🎓CC BY 4.0 — free for classrooms and LMS embeds

Frequently asked questions

Do I need to install anything to run Downstream Purification & Chromatography simulations?▾

No. Everything runs entirely in your browser — no downloads, plugins or accounts. Works in Chrome, Firefox, Edge and Safari; most simulations also work on mobile.

Can I use these simulations for teaching?▾

Yes — all content is free for educational use under CC BY 4.0. Link to any simulation directly or embed it in your LMS with an iframe; no API key required.

Are the models scientifically accurate?▾

They use the same mathematical formulations as professional software, integrated numerically in real time. Each simulation lists its algorithms, and many link to an article explaining the mathematics.

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