🧴 Isotretinoin Teratogenicity Risk Management (iPLEDGE) Simulator

Assessing Candidacy Before Isotretinoin Therapy Begins

Short placeholder: severe acne patient screened for pregnancy potential first.

• High: Teratogenic risk (placeholder caption text here)
• 1st: Screening step (placeholder caption text here)
• CBP: Population affected (placeholder caption text here)
• iPLEDGE: Program name (placeholder caption text here)

Why candidacy screening matters

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iPLEDGE Enrollment and Dual Contraception Counseling

Short placeholder: patient education plus two contraception methods required.

• 2: Contraception methods (placeholder caption text here)
• Multiple: Education topics (placeholder caption text here)
• REMS: Registry (placeholder caption text here)
• Required: Consent forms (placeholder caption text here)

Enrollment requirements overview

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The Monthly Pregnancy Test Verification Cycle

Short placeholder: negative test required in-window before each refill.

• 7 days: Test window (placeholder caption text here)
• Lab/office: Verification (placeholder caption text here)
• Monthly: Cycle frequency (placeholder caption text here)
• Test-linked: Refill gate (placeholder caption text here)

How the verification loop works

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Ongoing Monitoring Across the Full Treatment Course

Short placeholder: 30-day supply caps enforce monthly prescriber check-ins.

• 5-6 mo: Course length (placeholder caption text here)
• 30 days: Max supply (placeholder caption text here)
• Monthly: Prescriber visits (placeholder caption text here)
• Ongoing: Adherence checks (placeholder caption text here)

Monitoring cadence details

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Program Outcomes — Exposed Pregnancy Rate Reduction

Short placeholder: monthly checks cut exposed pregnancies, not eliminated.

• Higher: Pre-program rate (placeholder caption text here)
• Lower: iPLEDGE-era rate (placeholder caption text here)
• Nonzero: Residual risk (placeholder caption text here)
• Ongoing: Program status (placeholder caption text here)

What the outcome data shows

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