🧴 Eczema Atopic Dermatitis Biologic Therapy Simulator

Moderate-to-Severe Atopic Dermatitis at Baseline

Placeholder: widespread eczema plaques, high EASI, disrupted sleep.

• 21-72: Baseline EASI range (Placeholder short note)
• 6-9: Baseline itch NRS (Placeholder short note)
• 25-60%: BSA affected (Placeholder short note)
• 5-7: Sleep loss nights/wk (Placeholder short note)

Disease burden before treatment

Placeholder paragraph on baseline eczema severity and itch burden.

Loading Dose Then Biweekly Maintenance Begins

Placeholder: subcutaneous loading dose, then maintenance every two weeks.

• 600 mg: Loading dose (Placeholder short note)
• 300 mg: Maintenance dose (Placeholder short note)
• q2 weeks: Dosing interval (Placeholder short note)
• Subcutaneous: Route (Placeholder short note)

Starting the induction course

Placeholder paragraph on dupilumab dosing schedule start.

Weeks 1-4 — Pruritus Eases Before Skin Clears

Placeholder: itch NRS drops early, ahead of visible EASI change.

• ~50%: Itch improvement by wk2 (Placeholder short note)
• ~20%: EASI improvement by wk2 (Placeholder short note)
• Week 1-2: Sleep improvement onset (Placeholder short note)
• Itch < skin: Response lag (Placeholder short note)

Why itch responds first

Placeholder paragraph on early pruritus relief mechanism.

Weeks 4-16 — EASI Score Progressively Falls

Placeholder: plaques thin and fade as EASI trends downward weekly.

• Week 4-8: EASI-50 typically by (Placeholder short note)
• Week 16: EASI-75 typically by (Placeholder short note)
• Gradual: BSA reduction pattern (Placeholder short note)
• Every visit: Assessment interval (Placeholder short note)

Steady lesion clearance over weeks

Placeholder paragraph on progressive EASI decline pattern.

Most Patients Reach EASI-75 by Week 16

Placeholder: skin clears substantially and sleep quality improves.

• ~70%: EASI-75 responders (Placeholder short note)
• ~40%: EASI-90 responders (Placeholder short note)
• ~2: Itch NRS at week 16 (Placeholder short note)
• Marked: Sleep quality gain (Placeholder short note)

Reading the week-16 outcome

Placeholder paragraph summarizing the 16-week response pattern.

Placeholder highlight: itch relief precedes and outpaces skin clearance.