Moderate-to-Severe Atopic Dermatitis at Baseline
Placeholder: widespread eczema plaques, high EASI, disrupted sleep.
- 21-72: Baseline EASI range (Placeholder short note)
- 6-9: Baseline itch NRS (Placeholder short note)
- 25-60%: BSA affected (Placeholder short note)
- 5-7: Sleep loss nights/wk (Placeholder short note)
Disease burden before treatment
Placeholder paragraph on baseline eczema severity and itch burden.
Loading Dose Then Biweekly Maintenance Begins
Placeholder: subcutaneous loading dose, then maintenance every two weeks.
- 600 mg: Loading dose (Placeholder short note)
- 300 mg: Maintenance dose (Placeholder short note)
- q2 weeks: Dosing interval (Placeholder short note)
- Subcutaneous: Route (Placeholder short note)
Starting the induction course
Placeholder paragraph on dupilumab dosing schedule start.
Weeks 1-4 — Pruritus Eases Before Skin Clears
Placeholder: itch NRS drops early, ahead of visible EASI change.
- ~50%: Itch improvement by wk2 (Placeholder short note)
- ~20%: EASI improvement by wk2 (Placeholder short note)
- Week 1-2: Sleep improvement onset (Placeholder short note)
- Itch < skin: Response lag (Placeholder short note)
Why itch responds first
Placeholder paragraph on early pruritus relief mechanism.
Weeks 4-16 — EASI Score Progressively Falls
Placeholder: plaques thin and fade as EASI trends downward weekly.
- Week 4-8: EASI-50 typically by (Placeholder short note)
- Week 16: EASI-75 typically by (Placeholder short note)
- Gradual: BSA reduction pattern (Placeholder short note)
- Every visit: Assessment interval (Placeholder short note)
Steady lesion clearance over weeks
Placeholder paragraph on progressive EASI decline pattern.
Most Patients Reach EASI-75 by Week 16
Placeholder: skin clears substantially and sleep quality improves.
- ~70%: EASI-75 responders (Placeholder short note)
- ~40%: EASI-90 responders (Placeholder short note)
- ~2: Itch NRS at week 16 (Placeholder short note)
- Marked: Sleep quality gain (Placeholder short note)
Reading the week-16 outcome
Placeholder paragraph summarizing the 16-week response pattern.
Placeholder highlight: itch relief precedes and outpaces skin clearance.