🩸 PMDD Serotonin Sensitivity Simulator

Normal Hormone Fluctuation Baseline

Placeholder: a short overview of the normal menstrual hormone cycle.

• ~28d: Cycle length (Placeholder note)
• ~14: Ovulation day (Placeholder note)
• Mid-cycle: Estrogen peak (Placeholder note)
• Mid-luteal: Progesterone peak (Placeholder note)

Normal cyclical hormone rhythm

Placeholder: brief description of the normal hormone rhythm.

Placeholder highlight: this fluctuation is normal and expected.

Luteal Phase Hormone Shift

Placeholder: description of the post-ovulation luteal phase shift.

• ~14d: Luteal length (Placeholder note)
• Sharp: Progesterone rise (Placeholder note)
• Rapid: Late-luteal drop (Placeholder note)
• Normal: Hormone range (Placeholder note)

Luteal phase hormone dynamics

Placeholder: brief note on the luteal phase hormone shift.

Serotonin Receptor Hypersensitivity

Placeholder: description of abnormal serotonin receptor sensitivity in PMDD.

• Elevated: Receptor reactivity (Placeholder note)
• Normal levels: Trigger (Placeholder note)
• Serotonergic: Affected system (Placeholder note)
• Late luteal: Onset (Placeholder note)

Hypersensitive serotonergic response

Placeholder: brief note on receptor hypersensitivity mechanism.

Placeholder highlight: sensitivity, not hormone level, drives PMDD.

Abnormal Mood / Behavior Response

Placeholder: description of resulting mood and behavior symptoms.

• High: Irritability (Placeholder note)
• High: Mood lability (Placeholder note)
• Elevated: Anxiety (Placeholder note)
• Days: Duration (Placeholder note)

Mood and behavior symptom cascade

Placeholder: brief note on downstream mood symptoms.

Symptom Resolution with Menses

Placeholder: description of symptom relief once menses begins.

• Sharp: Hormone drop (Placeholder note)
• Within days: Symptom relief (Placeholder note)
• Day 1: Cycle restart (Placeholder note)
• Next cycle: Recurrence (Placeholder note)

Resolution at menses onset

Placeholder: brief note on symptom resolution timing.

Placeholder highlight: symptoms resolve then recur next cycle.