🔄 Early Menopause Premature Ovarian Insufficiency Simulator

Premature Ovarian Insufficiency — Menopause Before Age 40

Short placeholder: POI is loss of ovarian function before age 40.

• <40 yrs: Diagnosis threshold (Short placeholder note)
• ~1%: Prevalence (Short placeholder note)
• FSH ↑: Key hormone (Short placeholder note)
• ≥4 mo: Amenorrhea (Short placeholder note)

What defines POI

Short placeholder sentence describing diagnostic criteria and hormone pattern.

Autoimmune, Genetic, and Iatrogenic Causes of POI

Short placeholder: causes span autoimmune, genetic, iatrogenic, and idiopathic.

• ~20%: Autoimmune (Short placeholder note)
• ~20%: Genetic (e.g. FMR1) (Short placeholder note)
• Chemo/RT: Iatrogenic (Short placeholder note)
• ~50%: Idiopathic (Short placeholder note)

Etiology categories

Short placeholder sentence summarizing autoimmune, genetic, and iatrogenic mechanisms.

Bone and Cardiovascular Consequences of Early Estrogen Loss

Short placeholder: prolonged deficiency raises osteoporosis and CV disease risk.

• ↑: Fracture risk (Short placeholder note)
• ↑: CV disease risk (Short placeholder note)
• ↑: Cognitive risk (Short placeholder note)
• ↑ if untreated: Mortality (Short placeholder note)

Why early loss matters

Short placeholder sentence on cumulative estrogen deficiency exposure years.

Hormone Replacement Therapy Until Natural Menopause Age

Short placeholder: HRT recommended until roughly age 51 unless contraindicated.

• to ~51: Target duration (Short placeholder note)
• Protective: Bone benefit (Short placeholder note)
• Protective: CV benefit (Short placeholder note)
• Estrogen+progestin: Regimen (Short placeholder note)

Therapy rationale

Short placeholder sentence on replacing hormones lost by early failure.

Fertility Preservation Considerations in POI

Short placeholder: early counseling on oocyte or embryo banking is key.

• ~5–10%: Spontaneous pregnancy (Short placeholder note)
• Option: Donor oocyte (Short placeholder note)
• At diagnosis: Counseling timing (Short placeholder note)
• Recommended: Psych support (Short placeholder note)

Fertility pathways

Short placeholder sentence on preservation and family-building options.

Short placeholder highlight: discuss options promptly after diagnosis.