Ovarian Insufficiency Sim

Accelerated follicle depletion driving menopause before age 40 — POI causes, risks, and management.

Current Stage

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Estrogen deficiency yrs

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Bone/CV risk

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Likely cause

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Management

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Age at diagnosis28

Cause categoryIdiopathic

Depleted/atretic follicle

Active follicle (POI curve)

Normal aging reference curve

Diagnosis age marker

HRT coverage window

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Premature Ovarian Insufficiency — Menopause Before Age 40

Short placeholder: POI is loss of ovarian function before age 40.

<40 yrs: Diagnosis threshold (Short placeholder note)
~1%: Prevalence (Short placeholder note)
FSH ↑: Key hormone (Short placeholder note)
≥4 mo: Amenorrhea (Short placeholder note)

What defines POI

Short placeholder sentence describing diagnostic criteria and hormone pattern.

Autoimmune, Genetic, and Iatrogenic Causes of POI

Short placeholder: causes span autoimmune, genetic, iatrogenic, and idiopathic.

~20%: Autoimmune (Short placeholder note)
~20%: Genetic (e.g. FMR1) (Short placeholder note)
Chemo/RT: Iatrogenic (Short placeholder note)
~50%: Idiopathic (Short placeholder note)

Etiology categories

Short placeholder sentence summarizing autoimmune, genetic, and iatrogenic mechanisms.

Bone and Cardiovascular Consequences of Early Estrogen Loss

Short placeholder: prolonged deficiency raises osteoporosis and CV disease risk.

↑: Fracture risk (Short placeholder note)
↑: CV disease risk (Short placeholder note)
↑: Cognitive risk (Short placeholder note)
↑ if untreated: Mortality (Short placeholder note)

Why early loss matters

Short placeholder sentence on cumulative estrogen deficiency exposure years.

Hormone Replacement Therapy Until Natural Menopause Age

Short placeholder: HRT recommended until roughly age 51 unless contraindicated.

to ~51: Target duration (Short placeholder note)
Protective: Bone benefit (Short placeholder note)
Protective: CV benefit (Short placeholder note)
Estrogen+progestin: Regimen (Short placeholder note)

Therapy rationale

Short placeholder sentence on replacing hormones lost by early failure.

Fertility Preservation Considerations in POI

Short placeholder: early counseling on oocyte or embryo banking is key.

~5–10%: Spontaneous pregnancy (Short placeholder note)
Option: Donor oocyte (Short placeholder note)
At diagnosis: Counseling timing (Short placeholder note)
Recommended: Psych support (Short placeholder note)

Fertility pathways

Short placeholder sentence on preservation and family-building options.

Short placeholder highlight: discuss options promptly after diagnosis.