Home▸Peptic Ulcer Disease & H. pylori▸H. Pylori Triple/Quadruple Therapy Simulator

🩹 H. Pylori Triple/Quadruple Therapy Simulator

This simulator models eradication therapy for H. pylori, including triple or quadruple regimens with proton pump inhibitors (PPIs), amoxicillin, clarithromycin, and bismuth, as well as resistance to antibiotics and the percentage of eradication.

Peptic Ulcer Disease & H. pylori2DModerate60 FPS

H. Pylori Colonizes the Gastric Mucosa

H. pylori burrows through stomach mucus to reach the epithelial surface.

~50%: Global prevalence (placeholder statistic)
Helical: Shape (flagellated motility)
Mucus layer: Niche (urease neutralizes acid)
Ulcer/cancer: Outcome risk (placeholder statistic)

Colonization mechanism

Short placeholder text on flagellar motility and urease-driven acid neutralization.

PPI + Amoxicillin + Clarithromycin

Standard triple therapy combines acid suppression with two antibiotics.

14 days: Regimen length (placeholder statistic)
~85%: Historic success (placeholder statistic)
Clarithromycin: Key weakness (resistance-sensitive)
Acid suppression: PPI role (boosts antibiotic activity)

How triple therapy works

Short placeholder text describing combined antibiotic and acid-suppression action.

Clarithromycin Resistance Undermines Triple Therapy

Rising resistance rates sharply cut triple therapy success.

23S rRNA: Resistance driver (point mutations)
>15%: Threshold concern (placeholder statistic)
High: Regional variance (placeholder statistic)
Regimen failure: Consequence (placeholder statistic)

Resistance mechanism

Short placeholder text on ribosomal mutation blocking clarithromycin binding.

Bismuth Quadruple Therapy Alternative

Bismuth, metronidazole, tetracycline and a PPI bypass clarithromycin resistance.

10-14 days: Regimen length (placeholder statistic)
~90%: Success rate (placeholder statistic)
Low: Resistance dependence (placeholder statistic)
High-resistance areas: Use case (placeholder statistic)

Why quadruple therapy works

Short placeholder text on bismuth's multi-mechanism bactericidal action.

Confirming Eradication After Treatment

Urea breath or stool antigen testing verifies successful eradication.

Urea breath: Test type (placeholder statistic)
4+ weeks: Wait period (post-treatment)
High: Accuracy (placeholder statistic)
Switch regimen: Retreat if failed (placeholder statistic)

Confirmation protocol

Short placeholder text on retesting timing and next-line therapy choice.

⚙ Under the hood

CanvasBiomedicine

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install