🚽 Bladder Botox Injection Simulator

Cystoscopic Multi-Site Detrusor Injection

Placeholder: a rigid or flexible cystoscope guides a needle to inject the detrusor.

• 20: Injection sites (placeholder short caption)
• 100-200U: Dose range (placeholder short caption)
• ~10 min: Procedure time (placeholder short caption)
• Local: Anesthesia (placeholder short caption)

Injection technique

Placeholder short sentence describing the injection technique.

SNAP-25 Cleavage and Acetylcholine Release Blockade

Placeholder: toxin light chain cleaves SNAP-25 to stop ACh vesicle fusion.

• SNAP-25: Target protein (placeholder short caption)
• 3-7 days: Onset of effect (placeholder short caption)
• SNARE block: Mechanism (placeholder short caption)
• Type A: Toxin serotype (placeholder short caption)

Molecular blockade

Placeholder short sentence describing the molecular blockade step.

Reduced Involuntary Detrusor Contraction Frequency

Placeholder: overactive bladder contractions become less frequent and weaker.

• ~70%: Episode reduction (placeholder short caption)
• Improved: Continence gain (placeholder short caption)
• ~1 month: Peak benefit (placeholder short caption)
• Increased: Bladder capacity (placeholder short caption)

Functional effect

Placeholder short sentence describing the functional effect on contractions.

Effect Duration and Waning Over 6-9 Months

Placeholder: clinical benefit gradually declines as nerve terminals regenerate.

• 7.5 mo: Median duration (placeholder short caption)
• 6-9 mo: Range (placeholder short caption)
• Common: Repeat injections (placeholder short caption)
• Sprouting: Recovery mechanism (placeholder short caption)

Duration curve

Placeholder short sentence describing the effect duration curve.

Urinary Retention and Self-Catheterization Risk

Placeholder: higher doses raise risk of incomplete emptying needing self-cath.

• ~6-30%: Retention risk (placeholder short caption)
• Pre-procedure: Self-cath teaching (placeholder short caption)
• Higher at 200U: Dose dependence (placeholder short caption)
• Routine: PVR monitoring (placeholder short caption)

Retention management

Placeholder short sentence describing retention risk management.

Placeholder short callout about self-catheterization counseling.