Cystoscopic Multi-Site Detrusor Injection
Placeholder: a rigid or flexible cystoscope guides a needle to inject the detrusor.
- 20: Injection sites (placeholder short caption)
- 100-200U: Dose range (placeholder short caption)
- ~10 min: Procedure time (placeholder short caption)
- Local: Anesthesia (placeholder short caption)
Injection technique
Placeholder short sentence describing the injection technique.
SNAP-25 Cleavage and Acetylcholine Release Blockade
Placeholder: toxin light chain cleaves SNAP-25 to stop ACh vesicle fusion.
- SNAP-25: Target protein (placeholder short caption)
- 3-7 days: Onset of effect (placeholder short caption)
- SNARE block: Mechanism (placeholder short caption)
- Type A: Toxin serotype (placeholder short caption)
Molecular blockade
Placeholder short sentence describing the molecular blockade step.
Reduced Involuntary Detrusor Contraction Frequency
Placeholder: overactive bladder contractions become less frequent and weaker.
- ~70%: Episode reduction (placeholder short caption)
- Improved: Continence gain (placeholder short caption)
- ~1 month: Peak benefit (placeholder short caption)
- Increased: Bladder capacity (placeholder short caption)
Functional effect
Placeholder short sentence describing the functional effect on contractions.
Effect Duration and Waning Over 6-9 Months
Placeholder: clinical benefit gradually declines as nerve terminals regenerate.
- 7.5 mo: Median duration (placeholder short caption)
- 6-9 mo: Range (placeholder short caption)
- Common: Repeat injections (placeholder short caption)
- Sprouting: Recovery mechanism (placeholder short caption)
Duration curve
Placeholder short sentence describing the effect duration curve.
Urinary Retention and Self-Catheterization Risk
Placeholder: higher doses raise risk of incomplete emptying needing self-cath.
- ~6-30%: Retention risk (placeholder short caption)
- Pre-procedure: Self-cath teaching (placeholder short caption)
- Higher at 200U: Dose dependence (placeholder short caption)
- Routine: PVR monitoring (placeholder short caption)
Retention management
Placeholder short sentence describing retention risk management.
Placeholder short callout about self-catheterization counseling.