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Nanotopography Stem Cell Fate Simulator (2D)

Interactive 2D mechanotransduction simulator: tune nanoscale substrate topography (grooves, pillars), spacing, height and stiffness and watch a top-down stem-cell colony commit to osteogenic, myogenic, neurogenic or adipogenic fate via a real cytoskeletal-tension model, plus a side cross-section showing contractile stress-fiber tension.

Nanomedicine & Drug Delivery Materials2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

A colony of mesenchymal stem cells sits on a nanoscale substrate whose geometry and stiffness you control, viewed top-down. Switch between a flat surface, nanogrooves and a nanopillar array, tune the feature spacing and height, and slide substrate stiffness from soft to bone-hard — watch each cell's footprint, elongation and colour update live as it commits to an osteogenic, myogenic, neurogenic or adipogenic fate, driven by a simplified composite of the published mechanotransduction cues (Engler stiffness response, McBeath/Kilian RhoA-tension fate switch, Yim nanogroove-induced neuronal elongation, Dalby nanopillar-driven osteoinduction). A side cross-section panel shows the substrate profile and a hero cell's contractile stress-fiber tension directly.

⚙ Under the hood

Tune a nanopatterned substrate's grooves, pillars, spacing and stiffness and watch a top-down stem-cell colony commit to osteogenic, myogenic, neurogenic or adipogenic fate via a real cytoskeletal-tension mechanotransduction model, with a side cross-section showing contractile stress-fiber tension directly.

nanotechnologystem cellsmechanotransductiontissue engineeringregenerative medicinebiomaterials

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install