Macrophage M1/M2 Polarization Simulator

Macrophages are not fixed into two boxes — they sit on a continuous spectrum between the classically activated, pro-inflammatory M1 phenotype and the alternatively activated, pro-repair M2 phenotype, sliding along it as the local cytokine mix changes. This simulator places a population of macrophages in a 3D tissue volume and drives each one with the same relaxation model real receptor signaling follows: LPS/IFN-γ pulls a cell toward M1, IL-4/IL-13 pulls it toward M2, and a basal decay constantly pulls it back toward the resting M0 state. Turn the two cytokine sliders and watch the population repaint itself in real time — live readouts track the M1/M0/M2 fractions and the population's mean polarization index, the same summary statistic immunologists use to characterize a tissue's macrophage compartment in disease and repair.