Home▸Molecular Biology▸Axolotl Limb Blastema: Regeneration & Positional Patterning

Axolotl Limb Blastema: Regeneration & Positional Patterning

Interactive 3D simulator of axolotl limb regeneration: watch wound cells dedifferentiate into a blastema, control FGF, Wnt and BMP signalling strength, and see the HOX positional code pattern stylopod, zeugopod, autopod and digits back into place.

Molecular Biology3DModerate60 FPS📱 Mobile-adapted

Amputate an axolotl limb at three different levels and watch the actual cell biology of regeneration play out in 3D: wound fibroblasts dedifferentiate into a growing blastema, FGF and Wnt/β-catenin signalling drive its proliferation, and BMP signalling triggers redifferentiation back into position-appropriate tissue under a HOX positional code — stylopod, zeugopod, autopod, and finally the digits at the distal tip. Adjust the three signalling strengths to see how blastema size, growth speed, and patterning fidelity depend on each pathway, with live readouts for elapsed days, blastema cell count, and percentage of limb length restored.

⚙ Under the hood

Amputate an axolotl limb at three different levels and watch wound fibroblasts dedifferentiate into a blastema, driven by FGF and Wnt signalling, then redifferentiate under BMP control into position-correct stylopod, zeugopod, autopod and digit tissue guided by the HOX positional code.

regenerationaxolotlblastemadevelopmental-biologystem-cellshox-genes

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install