Home▸Molecular Biology▸Riboswitch Switch: 2D Ligand-Binding Curve & Folding Population

Riboswitch: Ligand-Gated Genetic Switch (2D)

Interactive 2D synthetic-biology riboswitch simulator: tune ligand concentration, aptamer affinity (Kd) and cooperativity (Hill coefficient), flip between ON-switch and OFF-switch riboswitch architectures, and watch an mRNA population fold between terminator and anti-terminator conformations on a draggable, zoomable 2D stage alongside a live Hill-isotherm plot.

Molecular Biology2DModerate60 FPS📱 Mobile-adapted⇄ 3D version

Details

CategoryMolecular Biology

RenderingCanvas 2D

DifficultyModerate

Target FPS60

ControlsSliders for ligand concentration [L], dissociation constant Kd, Hill coefficient n, and folding rate; ON-switch/OFF-switch toggle buttons; Reset population button re-seeds the mRNA states; Reset view button restores pan/zoom; drag the canvas to pan and scroll (or pinch on touch) to zoom.

riboswitchsynthetic biologygene regulationhill equationrna foldingaptamerligand binding

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Riboswitches are RNA elements that sense a small-molecule ligand directly and refold into one of two mutually exclusive structures — an expression-ON conformation or an expression-OFF conformation — without involving any protein. This 2D simulator models a population of 150 synthetic-biology mRNA molecules folding stochastically according to a real Hill-equation ligand-binding isotherm: tune ligand concentration, aptamer affinity (K_d) and cooperativity (Hill coefficient), flip the architecture between an ON-switch and an OFF-switch, and watch both the population and a central hero molecule morph live between the terminator-hairpin and anti-terminator conformations, alongside a live plot of the binding curve itself. Drag the stage to pan and scroll to zoom.

⚙ Under the hood

A 2D synthetic-biology riboswitch simulator: tune ligand concentration, aptamer affinity (Kd) and Hill cooperativity to drive a population of 150 mRNA molecules stochastically between terminator-hairpin and anti-terminator conformations, flip between ON-switch and OFF-switch architectures, and watch a live Hill-isotherm plot track the exact binding curve. Drag the stage to pan and scroll to zoom.

riboswitchsynthetic biologygene regulationhill equationrna foldingaptamerligand binding

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install