This simulator demonstrates how GHRH and somatostatin interact to produce pulsatile GH secretion, how GH drives hepatic IGF-1 production, and how IGF-1 feeds back to regulate the hypothalamus and pituitary.
Adjust the GHRH and somatostatin signal strengths to see how pituitary GH output, sleep-related pulses, and downstream IGF-1 levels change in real time, then observe how feedback loops readjust the system.
Sliders control GHRH and somatostatin strength, sleep state, and liver responsiveness, letting you observe real-time changes in pulsatile GH release and IGF-1 feedback.
Did you know that roughly 70% of a person's daily growth hormone output is released during the first few hours of deep sleep, which is one reason chronic sleep deprivation in children has been linked to slowed growth?
This simulator demonstrates how GHRH and somatostatin interact to produce pulsatile GH secretion, how GH drives hepatic IGF-1 production, and how IGF-1 feeds back to regulate the hypothalamus and pituitary.
This simulator demonstrates how GHRH and somatostatin interact to produce pulsatile GH secretion, how GH drives hepatic IGF-1 production, and how IGF-1 feeds back to regulate the hypothalamus and pituitary.
Adjust the GHRH and somatostatin signal strengths to see how pituitary GH output, sleep-related pulses, and downstream IGF-1 levels change in real time, then observe how feedback loops readjust the system.
Did you know that roughly 70% of a person's daily growth hormone output is released during the first few hours of deep sleep, which is one reason chronic sleep deprivation in children has been linked to slowed growth?