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MSC Paracrine Immunomodulation Simulator

3D simulation of mesenchymal stem cell therapy's paracrine mechanism: MSCs secrete a diffusible factor that repolarizes wound macrophages from a pro-inflammatory M1 state to a reparative M2 state, driving tissue healing.

Medicine & Biophysics3DModerate60 FPS📱 Mobile-adapted

This simulation renders the paracrine (signaling-based) mechanism of mesenchymal stem cell therapy in 3D: a dose of MSCs secretes a diffusible factor across a wound bed, and nearby macrophages — the immune cells that first arrive at any injury — gradually repolarize from a destructive M1 pro-inflammatory phenotype toward a reparative M2 phenotype as local factor concentration rises. Adjust the MSC dose, secretion potency, diffusion radius and the macrophages' baseline reversion rate to see when the therapy tips the wound's immune balance toward healing and when it doesn't, with live counts of M1 vs M2 macrophages and a healing index tracked in real time.

⚙ Under the hood

Watch mesenchymal stem cells repolarize wound macrophages from a pro-inflammatory M1 state to a reparative M2 state through a diffusible paracrine factor, the mechanism now thought to drive most of stem cell therapy's real clinical benefit.

stem cellsimmunologymacrophage polarizationregenerative medicineparacrine signaling

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install