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Sepsis Capillary Leak: Endothelial Barrier Breakdown

Interactive 3D Starling-Landis simulator of sepsis-induced capillary leak syndrome: watch cytokine storm intensity break down endothelial tight junctions, driving plasma and albumin from the vessel lumen into the interstitium while intravascular volume and blood pressure collapse.

Medicine & Biophysics3DAdvanced60 FPS📱 Mobile-adapted

This simulator renders a single capillary segment in 3D and models the Starling–Landis fluid-exchange equation that governs the vessel wall. As cytokine storm intensity rises, endothelial junctions visibly pull apart, letting plasma and then albumin escape into the surrounding tissue while intravascular volume, oncotic pressure and mean arterial pressure evolve in real time. Anti-cytokine therapy and IV fluid resuscitation are modeled as competing interventions, illustrating why fluids alone cannot fully compensate for a leaky vascular bed — the central physiological problem of septic shock.

⚙ Under the hood

Interactive 3D Starling-Landis simulator showing how a cytokine storm breaks down endothelial tight junctions, driving plasma and albumin out of a capillary into the interstitium while intravascular volume and blood pressure collapse.

sepsiscytokine stormcapillary leakendotheliumStarling equationcritical care

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install