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Polygenic Risk & Precision Medicine Simulator

Interactive precision-medicine simulator: toggle a patient's cardiovascular-risk gene variants, tune environmental factors and a genotype-aware statin therapy, and watch a live polygenic risk score, absolute 10-year risk and population percentile respond on a 3D DNA model.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted

Precision medicine tailors prevention and treatment to a patient's own genetic and environmental profile instead of a one-size-fits-all guideline. This simulator builds a live cardiovascular polygenic risk score from six real risk loci — APOE ε4, the 9p21.3 locus, LPA, gain-of-function PCSK9, MTHFR C677T and the statin-transporter gene SLCO1B1 — layers on modifiable environmental factors (BMI, exercise, smoking), and lets you start a genotype-aware statin therapy. A 3D DNA model lights each variant's rung red or green as you toggle it, a live risk bar tracks the computed 10-year absolute cardiovascular risk, and the population-percentile and statin myopathy readouts show exactly how genomic data analysis and targeted therapy decisions interact in real precision medicine.

⚙ Under the hood

This simulation allows users to explore the core principles of precision medicine – tailoring treatments to individual patients based on their unique genetic and environmental profiles. By manipulating variables related to genomic data analysis and targeted therapies, you can observe how these factors impact treatment outcomes and patient health.

Precision MedicineMedical2D

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install