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Partial Cellular Reprogramming: Epigenetic Age Reset vs. Teratoma Risk

Interactive 3D tissue model of partial cellular reprogramming (Yamanaka OSKM factors): reset epigenetic age, watch senescent cells spread bystander aging via SASP, clear them with senolytics, and see how pushing reprogramming too far triggers loss of cell identity.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted

This simulation models a 3D block of tissue where every cell carries an epigenetic age and a differentiated-identity state, and lets you drive it with the same lever real longevity research is exploring: partial reprogramming with the Yamanaka factors (Oct4, Sox2, Klf4, c-Myc — "OSKM"). Dial in the reprogramming dose and choose between a short protective pulse or sustained continuous exposure to watch cells rejuvenate — or, pushed too far, lose their differentiated identity and lock into a teratoma-risk state. Senescent cells spread a paracrine SASP signal that accelerates aging in their neighbours, and a senolytic-clearance control lets you remove and replace them, making the central trade-off of the field — rejuvenation versus genomic/identity instability — something you can watch play out cell by cell.

⚙ Under the hood

This simulation explores the complex theoretical pathways of achieving biological immortality through advanced genetic engineering and regenerative medicine techniques. Users will manipulate cellular processes to observe potential outcomes, highlighting both promising advancements and significant challenges.

Biological Immortality

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install