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🟡 Bilirubin Metabolism and Jaundice Thresholds

Follow heme breakdown into bilirubin through hepatic conjugation and biliary excretion, and see how hemolysis or liver dysfunction push levels past visible jaundice and kernicterus thresholds.

Medicine & Biophysics3DModerate60 FPS

The simulation traces bilirubin from red blood cell breakdown through hepatic conjugation and biliary excretion, showing how increased hemolysis or reduced liver conjugation capacity push bilirubin past the visible jaundice and kernicterus thresholds.

🔬 What It Demonstrates

🎮 How to Use

Adjust the hemolysis rate and liver conjugation capacity sliders to see bilirubin accumulate in the blood, and watch the 3D pathway highlight which processing step becomes the bottleneck as thresholds are crossed.

💡 Did You Know?

Phototherapy for newborn jaundice works by using blue light to chemically convert unconjugated bilirubin into a water-soluble form the body can excrete directly, completely bypassing the liver's immature conjugation enzyme.

⚙ Under the hood

Follow heme breakdown into bilirubin through hepatic conjugation and biliary excretion, and see how hemolysis or liver dysfunction push levels past visible jaundice and kernicterus thresholds.

bilirubinjaundiceliver metabolismhemolysiskernicterusheme breakdownneonatal jaundicebiochemistry

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install