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Proton Pump Inhibitor Trapping Field (2D)

2D reaction-diffusion field model of proton pump inhibitor ion-trapping: a diffusing drug concentration field crosses a pH gradient toward the acidic gastric canaliculus, converting to a trapped form by local Henderson-Hasselbalch equilibrium and covalently disabling proton pumps along the membrane.

Medicine & Biophysics2DModerate60 FPS📱 Mobile-adapted⇄ 3D version
2d-proton-pump-inhibitor-gastric-acid-suppression ↗ Open standalone

This is the 2D counterpart to the 3D proton-pump-inhibitor canaliculus simulator. Rather than animating discrete drug molecules diffusing through a 3D cutaway, it solves the same ion-trapping chemistry as a continuous reaction-diffusion field on a 2D grid: a mobile neutral-drug concentration diffuses across a spatial pH gradient from the neutral blood side toward the acidic canalicular membrane, converting locally into an immobile trapped form according to the Henderson-Hasselbalch equilibrium evaluated at each grid cell's own position. That trapped field then covalently disables proton pumps arrayed along the membrane, which recover only as fast as first-order protein synthesis allows once dosing stops. Watch the field itself pile up fastest right at the membrane where the local pH is lowest, and collapse instead when you raise canalicular pH toward neutral.

⚙ Under the hood

2D reaction-diffusion field model of proton pump inhibitor ion-trapping: a diffusing drug concentration field crosses a pH gradient toward the acidic gastric canaliculus, converting to a trapped form by local Henderson-Hasselbalch equilibrium and covalently disabling proton pumps along the membrane.

pharmacologygastric physiologyproton pumpPPIion trappingH+/K+-ATPase

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install

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