Cytology Slide: Nuclear Atypia Grader (2D)

Every diagnostic cytology reading — a cervical Pap smear, a thyroid or lung fine-needle aspirate — comes down to scoring a handful of nuclear features against the cell's cytoplasm. This top-down 2D companion to the 3D simulation renders the same 150-cell smear and lets you drive the four criteria a cytopathologist actually looks for: the nuclear-to-cytoplasmic ratio, chromatin hyperchromasia, nuclear pleomorphism (how much cells vary from each other) and the mitotic index. A live weighted atypia score maps the slide onto the same Normal → ASC-US → LSIL → HSIL → malignant spectrum used in the Bethesda System, so you can watch a benign-looking field of small dark nuclei and pale cytoplasm turn into the crowded, hyperchromatic, pleomorphic sheet of cells that sends a real specimen to biopsy. Drag to pan across the slide and scroll (or pinch) to zoom into individual cells.