iPSC Reprogramming Landscape: Yamanaka Factor Dosage (2D)

Somatic cells are trapped in a stable epigenetic well until a cocktail of transcription factors — OCT4, SOX2, KLF4 and MYC — remodels the landscape underneath them. This 2D simulator plots the real double-well potential curve directly: fifty cells (marbles) diffuse across it under overdamped Langevin dynamics while you titrate each factor's dosage and watch the barrier between the fibroblast well and the pluripotent well collapse in real time. A live population histogram and a scrolling efficiency-over-time trace sit alongside the landscape, and a stochastic-noise slider shows why real reprogramming is inefficient — most cells never make the crossing even once the landscape favors it. Drag the landscape to pan and scroll to zoom in on the barrier region.