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🦋 Sjögren's Syndrome Dry Eye & Mouth Simulator

This simulator illustrates the autoimmune damage to lacrimal and salivary glands in Sjögren's syndrome, visualizing lymphocytic infiltration and reduced secretion.

Lupus (SLE) & Related Autoimmune Conditions2DModerate60 FPS

Lymphocytic Infiltration of Exocrine Glands

Placeholder: autoimmune cells target lacrimal and salivary tissue.

≥1: Focus score threshold (Placeholder biopsy criterion)
CD4+ T: Main cell type (Placeholder infiltrate driver)
Anti-Ro/SSA: Autoantibodies (Placeholder marker)
~0.1-0.7%: Prevalence (Placeholder population rate)

Focal lymphocytic sialadenitis

Placeholder: periductal lymphocyte foci accumulate over time.

Lacrimal Gland Secretion Decline

Placeholder: reduced tear output damages the ocular surface.

<5mm/5min: Schirmer test (Placeholder diagnostic cutoff)
Elevated: Tear osmolarity (Placeholder marker)
Increased: Ocular staining (Placeholder finding)
Xerophthalmia: Symptom (Placeholder term)

Acinar cell loss and tear film instability

Placeholder: acinar atrophy lowers aqueous tear secretion.

Salivary Gland Secretion Decline

Placeholder: reduced saliva flow impairs oral function.

<0.1mL/min: Unstim. flow rate (Placeholder diagnostic cutoff)
Xerostomia: Symptom (Placeholder term)
Caries up: Dental risk (Placeholder complication)
Sialectasis: Imaging sign (Placeholder finding)

Ductal and acinar dysfunction

Placeholder: salivary acini shrink under sustained attack.

Systemic and Extraglandular Manifestations

Placeholder: disease can extend beyond glands over time.

Common: Fatigue (Placeholder symptom)
~50%: Arthralgia (Placeholder frequency)
~5-10x: Lymphoma risk (Placeholder relative risk)
Lung/kidney: Organ involvement (Placeholder sites)

Beyond the glands

Placeholder: chronic inflammation affects multiple organ systems.

Placeholder: monitor for lymphoma warning signs over time.

Symptomatic and Immunomodulatory Management

Placeholder: therapy targets symptoms and immune activity.

First-line: Artificial tears (Placeholder therapy)
Pilocarpine: Secretagogues (Placeholder drug class)
Hydroxychloroquine: Immunomodulation (Placeholder agent)
Regular: Monitoring (Placeholder follow-up)

Multimodal supportive care

Placeholder: combine lubrication, stimulation, and immune therapy.

⚙ Under the hood

This simulator illustrates the autoimmune damage to lacrimal and salivary glands in Sjögren's syndrome, visualizing lymphocytic infiltration and reduced secretion.

CanvasBiomedicine

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install