🩸 Iron Absorption & Transport Simulator

Apical Iron Uptake via DMT1

Placeholder: dietary iron enters enterocytes through the DMT1 channel.

• DMT1: Transporter (Placeholder note)
• Fe²⁺: Iron form (Placeholder note)
• Duodenum: Site (Placeholder note)
• DcytB: Cofactor (Placeholder note)

Apical membrane iron entry

Placeholder: brief note on DMT1-mediated ferrous iron import.

Basolateral Export via Ferroportin

Placeholder: ferroportin exports iron from enterocytes into blood.

• Ferroportin: Exporter (Placeholder note)
• Hephaestin: Oxidase (Placeholder note)
• Fe³⁺: Iron form (Placeholder note)
• Basolateral: Location (Placeholder note)

Export into circulation

Placeholder: brief note on ferroportin-mediated iron export.

Hepcidin Controls Ferroportin Availability

Placeholder: hepcidin degrades ferroportin to limit iron export.

• Hepcidin: Regulator (Placeholder note)
• Liver: Source (Placeholder note)
• Internalization: Effect (Placeholder note)
• Iron excess: Trigger (Placeholder note)

Negative feedback loop

Placeholder: brief note on hepcidin-ferroportin feedback control.

Transferrin Carries Iron Through Plasma

Placeholder: transferrin binds and ferries iron to tissues.

• Transferrin: Carrier (Placeholder note)
• TfR1: Receptor (Placeholder note)
• 2 Fe/molecule: Capacity (Placeholder note)
• Marrow, liver: Target (Placeholder note)

Plasma iron delivery

Placeholder: brief note on transferrin-mediated delivery.

Ferritin Stores and Releases Iron Reserves

Placeholder: ferritin shells buffer cellular iron reserves.

• Ferritin: Storage protein (Placeholder note)
• ~4500 Fe: Capacity (Placeholder note)
• Liver, spleen: Organs (Placeholder note)
• Serum ferritin: Marker (Placeholder note)

Storage and mobilization

Placeholder: brief note on ferritin storage dynamics.

Placeholder: short callout on iron storage/depletion balance.