Apical Iron Uptake via DMT1
Placeholder: dietary iron enters enterocytes through the DMT1 channel.
- DMT1: Transporter (Placeholder note)
- Fe²⁺: Iron form (Placeholder note)
- Duodenum: Site (Placeholder note)
- DcytB: Cofactor (Placeholder note)
Apical membrane iron entry
Placeholder: brief note on DMT1-mediated ferrous iron import.
Basolateral Export via Ferroportin
Placeholder: ferroportin exports iron from enterocytes into blood.
- Ferroportin: Exporter (Placeholder note)
- Hephaestin: Oxidase (Placeholder note)
- Fe³⁺: Iron form (Placeholder note)
- Basolateral: Location (Placeholder note)
Export into circulation
Placeholder: brief note on ferroportin-mediated iron export.
Hepcidin Controls Ferroportin Availability
Placeholder: hepcidin degrades ferroportin to limit iron export.
- Hepcidin: Regulator (Placeholder note)
- Liver: Source (Placeholder note)
- Internalization: Effect (Placeholder note)
- Iron excess: Trigger (Placeholder note)
Negative feedback loop
Placeholder: brief note on hepcidin-ferroportin feedback control.
Transferrin Carries Iron Through Plasma
Placeholder: transferrin binds and ferries iron to tissues.
- Transferrin: Carrier (Placeholder note)
- TfR1: Receptor (Placeholder note)
- 2 Fe/molecule: Capacity (Placeholder note)
- Marrow, liver: Target (Placeholder note)
Plasma iron delivery
Placeholder: brief note on transferrin-mediated delivery.
Ferritin Stores and Releases Iron Reserves
Placeholder: ferritin shells buffer cellular iron reserves.
- Ferritin: Storage protein (Placeholder note)
- ~4500 Fe: Capacity (Placeholder note)
- Liver, spleen: Organs (Placeholder note)
- Serum ferritin: Marker (Placeholder note)
Storage and mobilization
Placeholder: brief note on ferritin storage dynamics.
Placeholder: short callout on iron storage/depletion balance.