ACMG Variant Classification Scale

Clinical genomics labs don't call a variant "pathogenic" from a single data point — they combine independent evidence criteria under the ACMG/AMP framework, and the combination is what a report is built on. This simulator renders that combination as a physical balance: pathogenic evidence (very strong, strong, moderate) piles weighted spheres onto one pan, benign evidence piles onto the other, and the beam tilts by their net weight exactly as Tavtigian's Bayesian point system computes it. A live posterior-probability needle sweeps across the five reporting tiers — Pathogenic, Likely Pathogenic, VUS, Likely Benign, Benign — so you can see how a single new strong criterion, like a matching prior case in ClinVar, can flip a variant's clinical classification.