Synthetic Lethality Volcano-Swarm Plot (2D)

This 2D companion to the 3D interaction-grid simulator recasts the same pooled CRISPR double-knockout screen as the analysis chart real geneticists actually read: a volcano plot of effect size (ε = f_AB − f_A·f_B) against statistical significance (−log₁₀ p), with the hit-calling threshold drawn as a live dashed line. Every gene pair is a physical particle that settles into its data-driven position under a damped spring pulling it toward its true (ε, −log₁₀ p) coordinate and a softened repulsion pushing it away from overlapping neighbours — a real force-directed "beeswarm" layout, solved independently every frame rather than reusing the 3D scene's bar-height animation. Adjust replicate count and sequencing noise to watch the swarm tighten or spread, move the threshold to see the sensitivity/false-discovery-rate trade-off directly, and resample or regenerate the gene network to see how much a single run's result varies.