🧴 Atopic March Progression Simulator

Infant Eczema as the Entry Point of the Atopic March

Skin barrier dysfunction in infancy often starts the allergic cascade.

• 0–6mo: Typical onset (placeholder metric)
• FLG: Barrier gene (placeholder metric)
• ~15%: Prevalence (placeholder metric)
• High: Progression link (placeholder metric)

Skin barrier disruption

Placeholder: impaired barrier lets allergens penetrate early skin.

Food Allergy Sensitization Following Skin Exposure

Allergen contact through eczematous skin drives IgE sensitization.

• Egg/Peanut: Common trigger (placeholder metric)
• 6–24mo: Peak age (placeholder metric)
• Th2-driven: IgE pathway (placeholder metric)
• High w/ eczema: Co-occurrence (placeholder metric)

Dual-allergen exposure hypothesis

Placeholder: skin exposure sensitizes, gut exposure tolerizes.

Allergic Rhinitis Emerging in Early Childhood

Nasal mucosa reactivity develops as sensitization broadens.

• 2–5yr: Typical onset (placeholder metric)
• Aeroallergens: Trigger class (placeholder metric)
• ~20%: Prevalence (placeholder metric)
• Strong: Asthma link (placeholder metric)

Airway mucosa sensitization

Placeholder: rhinitis signals broadening systemic atopy.

Asthma Onset in Later Childhood

Airway inflammation and wheeze often appear by school age.

• 5–10yr: Typical onset (placeholder metric)
• 3–4x: Risk multiplier (placeholder metric)
• ~10%: Prevalence (placeholder metric)
• Final step: March completion (placeholder metric)

Airway remodeling risk

Placeholder: chronic inflammation drives airway changes.

Early Intervention to Alter the Atopic Trajectory

Barrier repair and early therapy may bend the march curve.

• Early use: Emollient therapy (placeholder metric)
• Early intro: Oral tolerance (placeholder metric)
• Moderate: Risk reduction (placeholder metric)
• First 2 years: Window (placeholder metric)

Preventive strategies

Placeholder: early barrier and allergen strategies show promise.

Placeholder: earlier intervention correlates with lower later-stage risk.