Infant Eczema as the Entry Point of the Atopic March
Skin barrier dysfunction in infancy often starts the allergic cascade.
- 0–6mo: Typical onset (placeholder metric)
- FLG: Barrier gene (placeholder metric)
- ~15%: Prevalence (placeholder metric)
- High: Progression link (placeholder metric)
Skin barrier disruption
Placeholder: impaired barrier lets allergens penetrate early skin.
Food Allergy Sensitization Following Skin Exposure
Allergen contact through eczematous skin drives IgE sensitization.
- Egg/Peanut: Common trigger (placeholder metric)
- 6–24mo: Peak age (placeholder metric)
- Th2-driven: IgE pathway (placeholder metric)
- High w/ eczema: Co-occurrence (placeholder metric)
Dual-allergen exposure hypothesis
Placeholder: skin exposure sensitizes, gut exposure tolerizes.
Allergic Rhinitis Emerging in Early Childhood
Nasal mucosa reactivity develops as sensitization broadens.
- 2–5yr: Typical onset (placeholder metric)
- Aeroallergens: Trigger class (placeholder metric)
- ~20%: Prevalence (placeholder metric)
- Strong: Asthma link (placeholder metric)
Airway mucosa sensitization
Placeholder: rhinitis signals broadening systemic atopy.
Asthma Onset in Later Childhood
Airway inflammation and wheeze often appear by school age.
- 5–10yr: Typical onset (placeholder metric)
- 3–4x: Risk multiplier (placeholder metric)
- ~10%: Prevalence (placeholder metric)
- Final step: March completion (placeholder metric)
Airway remodeling risk
Placeholder: chronic inflammation drives airway changes.
Early Intervention to Alter the Atopic Trajectory
Barrier repair and early therapy may bend the march curve.
- Early use: Emollient therapy (placeholder metric)
- Early intro: Oral tolerance (placeholder metric)
- Moderate: Risk reduction (placeholder metric)
- First 2 years: Window (placeholder metric)
Preventive strategies
Placeholder: early barrier and allergen strategies show promise.
Placeholder: earlier intervention correlates with lower later-stage risk.