💊 Contraceptive Implant Release-Kinetics Simulator

Insertion and the Initial Burst Release

Placeholder: the rod is inserted and hormone begins diffusing out right away.

• 4 cm: Rod length (Placeholder spec)
• 68 mg: Etonogestrel load (Placeholder spec)
• ~60-70 µg: Day-1 release (Placeholder value)
• Upper arm: Insertion site (Placeholder note)

What happens at insertion

Placeholder: brief note on subdermal placement and onset of diffusion.

Peak Blood Hormone Concentration

Placeholder: concentration reaches its highest point within the first weeks.

• ~1 month: Time to peak (Placeholder value)
• ~high: Peak level (Placeholder value)
• High: Protection (Placeholder note)
• Declining: Trend after peak (Placeholder note)

Why concentration peaks early

Placeholder: short note on initial diffusion gradient driving peak levels.

Steady-State Release Across Years 1-2

Placeholder: release rate stabilizes and stays well above the protective threshold.

• ~40 µg/day: Release rate (Placeholder value)
• ~24 months: Duration (Placeholder value)
• Adequate: Protection (Placeholder note)
• By metabolism: Variability (Placeholder note)

Maintaining protective levels

Placeholder: short note on plateaued diffusion and consistent contraceptive coverage.

Declining Release Approaching Year 3

Placeholder: as the core depletes, release rate and blood levels taper down.

• ~25-30 µg/day: Release rate (Placeholder value)
• Advancing: Core depletion (Placeholder note)
• Reduced risk: Protection (Placeholder note)
• Recommended: Monitoring (Placeholder note)

Tapering kinetics near depletion

Placeholder: short note on diminishing reservoir and slower diffusion.

Removal and Replacement Timing

Placeholder: replacement is advised once protection nears its lower bound.

• 3 years: Labeled duration (Placeholder spec)
• Month 36: Replacement window (Placeholder value)
• Low: Protection at end (Placeholder note)
• Removal + reinsertion: Procedure (Placeholder note)

Timing the swap

Placeholder: short note on removing depleted rod and inserting a new one.

Placeholder: replace by month 36 to maintain uninterrupted contraceptive protection.