Insertion and the Initial Burst Release
Placeholder: the rod is inserted and hormone begins diffusing out right away.
- 4 cm: Rod length (Placeholder spec)
- 68 mg: Etonogestrel load (Placeholder spec)
- ~60-70 µg: Day-1 release (Placeholder value)
- Upper arm: Insertion site (Placeholder note)
What happens at insertion
Placeholder: brief note on subdermal placement and onset of diffusion.
Peak Blood Hormone Concentration
Placeholder: concentration reaches its highest point within the first weeks.
- ~1 month: Time to peak (Placeholder value)
- ~high: Peak level (Placeholder value)
- High: Protection (Placeholder note)
- Declining: Trend after peak (Placeholder note)
Why concentration peaks early
Placeholder: short note on initial diffusion gradient driving peak levels.
Steady-State Release Across Years 1-2
Placeholder: release rate stabilizes and stays well above the protective threshold.
- ~40 µg/day: Release rate (Placeholder value)
- ~24 months: Duration (Placeholder value)
- Adequate: Protection (Placeholder note)
- By metabolism: Variability (Placeholder note)
Maintaining protective levels
Placeholder: short note on plateaued diffusion and consistent contraceptive coverage.
Declining Release Approaching Year 3
Placeholder: as the core depletes, release rate and blood levels taper down.
- ~25-30 µg/day: Release rate (Placeholder value)
- Advancing: Core depletion (Placeholder note)
- Reduced risk: Protection (Placeholder note)
- Recommended: Monitoring (Placeholder note)
Tapering kinetics near depletion
Placeholder: short note on diminishing reservoir and slower diffusion.
Removal and Replacement Timing
Placeholder: replacement is advised once protection nears its lower bound.
- 3 years: Labeled duration (Placeholder spec)
- Month 36: Replacement window (Placeholder value)
- Low: Protection at end (Placeholder note)
- Removal + reinsertion: Procedure (Placeholder note)
Timing the swap
Placeholder: short note on removing depleted rod and inserting a new one.
Placeholder: replace by month 36 to maintain uninterrupted contraceptive protection.