HomeBioinformaticsAI Protein Fitness Landscape Explorer

AI Protein Fitness Landscape Explorer

Interactive 3D protein-engineering simulator: candidate sequences climb a stability / binding-affinity / developability fitness landscape across generations of an AI-guided design-build-test cycle.

Bioinformatics3DAdvanced60 FPS📱 Mobile-adapted⇄ 2D version
biology-ext-topic-23 ↗ Open standalone

AI-driven protein design rarely optimizes one number — a sequence that binds tighter is often less stable or more prone to aggregate. This simulator renders that trade-off as a real 3D terrain: every candidate sequence is a point scored by simplified stability (ΔΔG), binding-affinity (pKD) and aggregation-propensity models, combined into one fitness height. Each "Run cycle" click plays out one round of a design-build-test loop — the AI proposes a new pool of candidates around the current best, scores them, filters out the ones that fail a developability cutoff, and promotes the new peak — while live readouts track how many candidates pass, and the predicted KD and ΔΔG of the current leader.

⚙ Under the hood

Interactive 3D protein-engineering simulator where candidate sequences climb a stability / binding-affinity / developability fitness landscape across generations of an AI-guided design-build-test cycle.

protein designAIbioinformaticsdirected evolutionfitness landscapebinding affinity

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install

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