🏥 Combined Bariatric Surgery Plus GLP-1 Simulator

Post-Bariatric Plateau — Placeholder Title

Short placeholder: surgery drives early loss then weight stalls.

• 25%: Typical surgical loss (placeholder sub-caption)
• ~12 mo: Plateau onset (placeholder sub-caption)
• 20–30%: Regain risk (placeholder sub-caption)
• ~1 in 4: Patients affected (placeholder sub-caption)

Why weight loss plateaus after surgery

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Adding GLP-1 Therapy — Placeholder Title

Short placeholder: pharmacologic therapy layered onto surgical anatomy.

• Semaglutide: GLP-1 agents used (placeholder sub-caption)
• 0.25mg: Typical starting dose (placeholder sub-caption)
• ~16 wk: Titration window (placeholder sub-caption)
• Plateau/regain: Eligible candidates (placeholder sub-caption)

Appetite-suppression mechanism added

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Restriction Plus Suppression — Placeholder Title

Short placeholder: two mechanisms act on appetite and intake simultaneously.

• Restriction: Surgical mechanism (placeholder sub-caption)
• Appetite axis: Pharmacologic mechanism (placeholder sub-caption)
• GLP-1R: Receptor target (placeholder sub-caption)
• ~1–2 mo: Onset of synergy (placeholder sub-caption)

How the two mechanisms interact

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Extra Monthly Loss — Placeholder Title

Short placeholder: combined monthly loss exceeds either therapy alone.

• ~8–10%: Added loss (6 mo) (placeholder sub-caption)
• Mostly additive: Additive vs. synergistic (placeholder sub-caption)
• Reduced: Plateau resistance (placeholder sub-caption)
• Monthly: Follow-up cadence (placeholder sub-caption)

Tracking the additive trajectory

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Total Trajectory vs. Plateau — Placeholder Title

Short placeholder: combined outcome compared to surgery-alone plateau.

• ~35–40%: Combined total loss (placeholder sub-caption)
• ~25%: Surgery-alone plateau (placeholder sub-caption)
• +10–15%: Net gain from GLP-1 (placeholder sub-caption)
• Sustained: Durability (placeholder sub-caption)

Comparing combined vs. surgery-alone outcomes

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