Surgery + GLP-1

Pharmacologic boost to surgical weight loss after plateau or regain

Current Stage

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Months on GLP-1

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Surgery-alone loss

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Added by GLP-1

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Combined total loss

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Months since GLP-1 start0

GLP-1 dose levelNone

Surgery-alone trajectory

Combined trajectory

GLP-1 signal / added loss

Surgical anatomy (pouch/sleeve)

GLP-1 initiation point

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Post-Bariatric Plateau — Placeholder Title

Short placeholder: surgery drives early loss then weight stalls.

25%: Typical surgical loss (placeholder sub-caption)
~12 mo: Plateau onset (placeholder sub-caption)
20–30%: Regain risk (placeholder sub-caption)
~1 in 4: Patients affected (placeholder sub-caption)

Why weight loss plateaus after surgery

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Adding GLP-1 Therapy — Placeholder Title

Short placeholder: pharmacologic therapy layered onto surgical anatomy.

Semaglutide: GLP-1 agents used (placeholder sub-caption)
0.25mg: Typical starting dose (placeholder sub-caption)
~16 wk: Titration window (placeholder sub-caption)
Plateau/regain: Eligible candidates (placeholder sub-caption)

Appetite-suppression mechanism added

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Restriction Plus Suppression — Placeholder Title

Short placeholder: two mechanisms act on appetite and intake simultaneously.

Restriction: Surgical mechanism (placeholder sub-caption)
Appetite axis: Pharmacologic mechanism (placeholder sub-caption)
GLP-1R: Receptor target (placeholder sub-caption)
~1–2 mo: Onset of synergy (placeholder sub-caption)

How the two mechanisms interact

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Extra Monthly Loss — Placeholder Title

Short placeholder: combined monthly loss exceeds either therapy alone.

~8–10%: Added loss (6 mo) (placeholder sub-caption)
Mostly additive: Additive vs. synergistic (placeholder sub-caption)
Reduced: Plateau resistance (placeholder sub-caption)
Monthly: Follow-up cadence (placeholder sub-caption)

Tracking the additive trajectory

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Total Trajectory vs. Plateau — Placeholder Title

Short placeholder: combined outcome compared to surgery-alone plateau.

~35–40%: Combined total loss (placeholder sub-caption)
~25%: Surgery-alone plateau (placeholder sub-caption)
+10–15%: Net gain from GLP-1 (placeholder sub-caption)
Sustained: Durability (placeholder sub-caption)

Comparing combined vs. surgery-alone outcomes

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