🩸 Blood-Based p-Tau217 Alzheimer's Screening Simulator

A Simple Blood Draw Replacing Invasive Diagnostics

Placeholder: comparing venipuncture convenience to PET and lumbar puncture.

• Plasma: Sample type (Placeholder sub-label)
• ~5 min: Draw time (Placeholder sub-label)
• $$$$: PET scan cost (Placeholder sub-label)
• Invasive: CSF procedure (Placeholder sub-label)

Blood draw workflow placeholder heading

Placeholder: short description of the blood draw pipeline versus imaging.

p-Tau217 as a Proxy for Brain Pathology

Placeholder: phosphorylated tau at 217 reflects amyloid and tangle burden.

• p-Tau217: Biomarker (Placeholder sub-label)
• Blood plasma: Source tissue (Placeholder sub-label)
• Tau tangles: Target pathology (Placeholder sub-label)
• Immunoassay: Detection method (Placeholder sub-label)

Biomarker biology placeholder heading

Placeholder: short description of tau phosphorylation and blood transit.

Correlating Plasma Levels with PET and CSF

Placeholder: statistical agreement between blood, imaging, and spinal fluid.

• 0.90+: Correlation (r) (Placeholder sub-label)
• Amyloid PET: Reference standard (Placeholder sub-label)
• CSF p-Tau: Secondary standard (Placeholder sub-label)
• 1000s: Cohort size (Placeholder sub-label)

Correlation study placeholder heading

Placeholder: short description of validation cohorts and scatter agreement.

Interpreting Diagnostic Thresholds

Placeholder: dividing results into negative, intermediate, and positive zones.

• Low: Negative zone (Placeholder sub-label)
• Grey area: Intermediate zone (Placeholder sub-label)
• High: Positive zone (Placeholder sub-label)
• Yes: Two-cutoff model (Placeholder sub-label)

Threshold model placeholder heading

Placeholder: short description of cutoff derivation and grey zone handling.

Bringing the Test into Primary Care

Placeholder: enabling earlier referral decisions in general practice.

• Primary care: Setting (Placeholder sub-label)
• Days: Turnaround (Placeholder sub-label)
• Faster: Referral impact (Placeholder sub-label)
• Broader: Access gain (Placeholder sub-label)

Care pathway placeholder heading

Placeholder: short description of screening-to-specialist referral flow.

Placeholder: key insight about scaling screening to general population.