A Simple Blood Draw Replacing Invasive Diagnostics
Placeholder: comparing venipuncture convenience to PET and lumbar puncture.
- Plasma: Sample type (Placeholder sub-label)
- ~5 min: Draw time (Placeholder sub-label)
- $$$$: PET scan cost (Placeholder sub-label)
- Invasive: CSF procedure (Placeholder sub-label)
Blood draw workflow placeholder heading
Placeholder: short description of the blood draw pipeline versus imaging.
p-Tau217 as a Proxy for Brain Pathology
Placeholder: phosphorylated tau at 217 reflects amyloid and tangle burden.
- p-Tau217: Biomarker (Placeholder sub-label)
- Blood plasma: Source tissue (Placeholder sub-label)
- Tau tangles: Target pathology (Placeholder sub-label)
- Immunoassay: Detection method (Placeholder sub-label)
Biomarker biology placeholder heading
Placeholder: short description of tau phosphorylation and blood transit.
Correlating Plasma Levels with PET and CSF
Placeholder: statistical agreement between blood, imaging, and spinal fluid.
- 0.90+: Correlation (r) (Placeholder sub-label)
- Amyloid PET: Reference standard (Placeholder sub-label)
- CSF p-Tau: Secondary standard (Placeholder sub-label)
- 1000s: Cohort size (Placeholder sub-label)
Correlation study placeholder heading
Placeholder: short description of validation cohorts and scatter agreement.
Interpreting Diagnostic Thresholds
Placeholder: dividing results into negative, intermediate, and positive zones.
- Low: Negative zone (Placeholder sub-label)
- Grey area: Intermediate zone (Placeholder sub-label)
- High: Positive zone (Placeholder sub-label)
- Yes: Two-cutoff model (Placeholder sub-label)
Threshold model placeholder heading
Placeholder: short description of cutoff derivation and grey zone handling.
Bringing the Test into Primary Care
Placeholder: enabling earlier referral decisions in general practice.
- Primary care: Setting (Placeholder sub-label)
- Days: Turnaround (Placeholder sub-label)
- Faster: Referral impact (Placeholder sub-label)
- Broader: Access gain (Placeholder sub-label)
Care pathway placeholder heading
Placeholder: short description of screening-to-specialist referral flow.
Placeholder: key insight about scaling screening to general population.