☀️ Vitamin D Supplementation Dosing Simulator

Measuring Baseline 25-Hydroxyvitamin D

Placeholder: serum 25-OH-D defines deficiency severity before dosing begins.

• <20 ng/mL: Deficient (placeholder threshold)
• 20–29 ng/mL: Insufficient (placeholder threshold)
• 30–50 ng/mL: Sufficient (target range)
• 25-OH-D: Assay (best status marker)

Why 25-OH-D is measured

Placeholder: 25-OH-D is the stable circulating form used for status.

Severity classification

Placeholder: mild, moderate, severe bands set the treatment plan.

Calculating the Weight-Adjusted Repletion Dose

Placeholder: higher severity and higher body weight both raise the starting dose.

• 50,000 IU/wk: Typical dose (placeholder regimen)
• 6–12 wks: Duration (severity-dependent)
• 0.7–1.6×: Weight factor (placeholder scaling)
• D3: Form (cholecalciferol)

Severity-based starting dose

Placeholder: more severe deficiency gets a higher weekly dose.

Weight adjustment

Placeholder: heavier patients need proportionally more IU.

Blood Level Rising Toward the Target Range

Placeholder: weekly high-dose repletion raises 25-OH-D over several weeks.

• Saturating: Rise pattern (placeholder curve shape)
• ~8–12 wks: Recheck (placeholder interval)
• 30–50 ng/mL: Target (placeholder band)
• 25-OH-D: Monitoring (repeat assay)

Trajectory shape

Placeholder: level rises fastest early, then approaches target.

Monitoring cadence

Placeholder: recheck level before switching dosing phase.

Switching From Repletion to Maintenance Dosing

Placeholder: once target is reached, dose drops sharply to a daily maintenance level.

• 1,000–2,000 IU/day: Maintenance (placeholder range)
• Target reached: Trigger (placeholder rule)
• ~90%: Dose drop (placeholder magnitude)
• Overshoot: Risk if skipped (placeholder note)

Why the dose drops

Placeholder: repletion doses are too high for long-term daily use.

Maintenance sizing

Placeholder: daily dose keeps level steady near target.

Appropriate Dosing Achieves and Sustains Target Level

Placeholder: correct dosing hits target efficiently; mis-dosing under- or overshoots.

• Slow rise: Under-dosing (placeholder outcome)
• On target: Correct dosing (placeholder outcome)
• Toxicity risk: Over-dosing (placeholder — rare)
• >100 ng/mL: Toxicity level (placeholder threshold)

Under- vs over-dosing

Placeholder: too little dose delays repletion; too much risks toxicity.

Long-term maintenance

Placeholder: adjusted daily dose keeps level in range indefinitely.