Home▸Transplant Immunology & Organ Preservation▸Hyperacute Rejection 2D: Vessel Cross-Section Occlusion Model

Hyperacute Rejection 2D: Vessel Cross-Section Occlusion Model

Interactive 2D simulator of hyperacute transplant rejection: watch antibody binding and complement-driven thrombus growth along an unrolled vessel wall, scrub a live cross-section to see the lumen narrow, and track occlusion over time — tune antibody titer, ABO/HLA mismatch and complement activity.

Transplant Immunology & Organ Preservation2DAdvanced60 FPS📱 Mobile-adapted⇄ 3D version

This simulator models the fastest and most destructive form of transplant rejection: hyperacute rejection, in which antibodies the recipient already carries — from ABO incompatibility or prior HLA sensitization — bind donor endothelial antigens the moment the graft is reperfused. Every bound antigen site activates the complement cascade, triggers platelet and fibrin deposition, and builds a thrombus that narrows the vessel lumen in real time. This 2D rendition unrolls the vessel wall into a lengthwise strip, lets you drag a marker to scrub a live lumen cross-section at any point along the graft, and charts occlusion and bound-site count over simulated time. Tune antibody titer, donor–recipient mismatch severity and complement activity to see why a negative crossmatch before surgery is non-negotiable.

⚙ Under the hood

A 2D unrolled-vessel model of hyperacute transplant rejection: preformed antibodies bind donor endothelial antigens along a lengthwise wall strip, activate complement, and build a thrombus — drag or scrub a marker to inspect a live lumen cross-section at any point along the graft while a strip chart tracks occlusion and bound-site count over time.

transplantimmunologyrejectioncomplementhemodynamicsmedicine2D model

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install