❤️ Flibanserin & Bremelanotide Mechanism Simulator

Low Sexual Desire — Starting Point

Baseline circuit activity before pharmacologic intervention begins.

• ~10%: HSDD prevalence (placeholder estimate)
• Elevated: Serotonin tone (placeholder baseline)
• Low: Melanocortin tone (placeholder baseline)
• Low: Desire response (placeholder baseline)

Baseline neurocircuitry

Placeholder: excitatory and inhibitory desire pathways sit imbalanced.

Flibanserin — Daily Serotonin Modulator

Flibanserin is taken daily to rebalance serotonin receptor signaling.

• 100 mg/day: Dosing (placeholder regimen)
• Weeks: Onset (placeholder timeline)
• 5-HT1A/2A: Target (placeholder receptors)
• Multifunctional: Class (placeholder label)

Daily oral mechanism

Placeholder: drug crosses blood-brain barrier and binds serotonin receptors.

Serotonin Receptor Modulation Over Time

Gradual receptor changes accumulate with continued daily dosing.

• Agonized: 5-HT1A (placeholder direction)
• Antagonized: 5-HT2A (placeholder direction)
• ~4 wks: Full effect (placeholder timeline)
• On stop: Reversal (placeholder note)

Cumulative modulation

Placeholder: receptor tone shifts slowly across the dosing period.

Bremelanotide — On-Demand Melanocortin Agonist

Bremelanotide is self-injected shortly before anticipated activity.

• On-demand: Dosing (placeholder regimen)
• Subcutaneous: Route (placeholder route)
• MC4R: Target (placeholder receptor)
• ~45 min: Onset (placeholder timeline)

Rapid receptor engagement

Placeholder: injected drug quickly reaches hypothalamic melanocortin receptors.

Melanocortin Receptor Activation Spike

MC4R activation rises sharply then fades after the dose wears off.

• Sharp spike: Peak activation (placeholder pattern)
• Hours: Duration (placeholder timeline)
• Nausea/flushing: Side effects (placeholder note)
• 8/month: Frequency cap (placeholder limit)

Peak response window

Placeholder: desire response peaks then declines as drug clears.