🤧 Pollen Count & Histamine Release Simulator (3D)

Seasonal Pollen Concentration in a 3D Nasal Airway

Airborne pollen levels shift with season and weather; here the grains fall through a genuine 3D air volume above a deformable nasal-mucosa surface instead of a flat 2D scene.

• 800+: Peak season count (grains/m³ placeholder)
• <50: Low season count (grains/m³ placeholder)
• Trees/grass: Main sources (seasonal placeholder)
• High: Wind effect (placeholder factor)

Pollen count variability

Orbit the 3D scene to see grains drift and settle across the full mucosal surface, not just a single 2D cross-section.

Higher pollen counts fill more of the air volume with grains before they reach the mucosa.

Pollen Deposition on the Nasal Mucosa

Inhaled grains settle onto the moist, wavy nasal lining, modeled here as a deforming 3D mesh.

• ~60%: Deposition rate (placeholder estimate)
• 20-50µm: Grain size (placeholder range)
• Turbinates: Contact zone (placeholder region)
• Trapping: Mucus role (placeholder function)

Mucosal deposition mechanics

Grains landing on the mucosa surface are marked and held at the local surface height, following the same landing rule as the 2D model, now applied per (x,z) location.

Deposition follows the true surface contour rather than a single mucosa line.

IgE-Mediated Mast Cell Histamine Release

Allergen cross-links IgE, triggering mast cell degranulation, visualized as red particle bursts rising from landing sites.

• <1 min: Trigger time (placeholder latency)
• Histamine: Mediator (placeholder mediator)
• FcεRI: Receptor (placeholder receptor)
• Mast cells: Cell type (placeholder source)

Degranulation pathway

Each landed grain has a chance to trigger a burst once the IgE stage begins, matching the 2D model's spawn probability.

Sensitization strength scales how strongly histamine release maps to symptom severity.

Sneezing, Congestion, and Itch Response

Histamine drives the classic allergic rhinitis symptom triad, read out live in the symptom cascade panel.

• Minutes: Sneeze onset (placeholder timing)
• Delayed: Congestion (placeholder phase)
• Histamine: Itch mediator (placeholder mediator)
• Hours: Duration (placeholder duration)

Symptom progression

Sneeze and itch bars track symptom severity directly, congestion tracks the nasal congestion metric.

Severity is driven mostly by histamine release, with a smaller direct sensitivity term.

Predicting Symptoms From Pollen Forecasts

Forecast data lets patients anticipate allergy symptom risk over the next several days.

• 3-5 days: Forecast horizon (placeholder horizon)
• Moderate: Accuracy (placeholder accuracy)
• Pre-medication: Use case (placeholder use)
• Pollen stations: Data source (placeholder source)

Forecast-driven planning

The 5-day trend line oscillates around the current histamine level, the same formula used in the 2D original.

Forecast risk bands (low/moderate/high) use the same 0.3/0.6 histamine thresholds as the 2D model.