🔬 PSA Trend Post-Treatment Surveillance Simulator

The Post-Treatment PSA Nadir

Placeholder lead: baseline PSA after successful initial treatment.

• <0.2 ng/mL: Typical nadir (placeholder caption text)
• ~3–6 mo: Time to nadir (placeholder caption text)
• 0.01 ng/mL: Assay sensitivity (placeholder caption text)
• Post-op/RT: Surveillance start (placeholder caption text)

Establishing the baseline

Placeholder body text: nadir sets the reference point for future rises.

Serial PSA Values Over Follow-Up

Placeholder lead: repeated PSA draws build the surveillance trend.

• 3 mo: Typical interval (placeholder caption text)
• 0–24 mo: Follow-up window (placeholder caption text)
• ~10%: Assay variability (placeholder caption text)
• ≥3: Points needed (placeholder caption text)

Building the trend line

Placeholder body text: multiple points reduce single-assay noise.

PSA Rise Signals Recurrence Before Imaging

Placeholder lead: rising PSA precedes clinical or radiographic findings.

• +2 ng/mL: Recurrence threshold (placeholder caption text)
• Months–yrs: Lead time vs imaging (placeholder caption text)
• 2 consecutive: Confirmatory draws (placeholder caption text)
• Serial PSA: Detection method (placeholder caption text)

Earliest detectable signal

Placeholder body text: rising trend triggers closer surveillance.

Calculating PSA Doubling Time

Placeholder lead: exponential fit yields the doubling-time estimate.

• ln2 / k: Formula (placeholder caption text)
• Log-linear: Fit method (placeholder caption text)
• <3 mo: Fast PSADT (placeholder caption text)
• >12 mo: Slow PSADT (placeholder caption text)

From slope to doubling time

Placeholder body text: growth constant k converts to a doubling interval.

Short vs Long PSADT — Aggressiveness Stratification

Placeholder lead: doubling time guides urgency of intervention.

• <3 mo: Short PSADT (placeholder caption text)
• >12 mo: Long PSADT (placeholder caption text)
• Prompt tx: Aggressive action (placeholder caption text)
• Observation: Indolent action (placeholder caption text)

Matching management to risk

Placeholder body text: PSADT stratifies aggressive vs indolent recurrence.

Placeholder highlight: short doubling time warrants prompt clinical action.