EN 
Українська
PolskiNext-Generation Hormonal Therapy (Abiraterone/Enzalutamide) Simulator (3D)
A real 3D pathway simulation of two castration-resistant prostate cancer blockade points — abiraterone's upstream CYP17 shutdown vs enzalutamide's androgen-receptor blockade — rendered as an orbitable source cell → enzyme checkpoint → receptor cell pathway with molecules that physically bounce off whichever node the active drug blocks.
Castration-resistant prostate cancer keeps signaling through the androgen receptor even after the testes are chemically silenced, because adrenal glands and the tumor itself keep synthesizing small amounts of androgen. Two drug classes interrupt that residual signal at different points: abiraterone blocks CYP17A1, the enzyme that builds androgen precursors, cutting off supply at the source; enzalutamide instead blocks the androgen receptor itself, so any androgen that does form can no longer dock and signal. This 3D simulator renders both blockade points as real spatial checkpoints — a source cell, an enzyme node, and a receptor cell laid out along one axis — and lets you orbit the whole pathway while molecules stream from source to receptor, deflecting off whichever checkpoint the selected drug and dose level are currently blocking.
Ports the 2D original's exact blockade logic — supply-block chance and receptor-block chance both scale as dose×0.9 when the corresponding drug is active per stage — into a real 3D pathway: an orbitable source cell, an enzyme checkpoint (CYP17) and a receptor cell (with nucleus and AR docking site) spaced along one world axis, with molecules that physically travel, deflect and flash in three dimensions.
3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install