🩺 Low-Dose Aspirin Prophylaxis Simulator

Identifying High-Risk Pregnancies for Aspirin Prophylaxis

High-risk criteria guide who should start prophylaxis early.

• High risk: Prior preeclampsia (single major factor)
• High risk: Chronic hypertension (single major factor)
• ≥2 needed: Moderate factors (combined threshold)
• First visit: Screening timing (before 12–16 wks)

Major and moderate risk factors

Short placeholder: major factors alone qualify; moderate factors need combination.

The Critical Window — Starting Aspirin by 16 Weeks

Benefit depends heavily on starting before placentation completes.

• 12 wks: Ideal start (placeholder value)
• 16 wks: Latest effective (placeholder cutoff)
• Low benefit: After 20 wks (placeholder estimate)
• 6–18 wks: Remodeling phase (placeholder range)

Why timing matters

Short placeholder: spiral artery remodeling finishes early, limiting later benefit.

Thromboxane A2 Suppression by Low-Dose Aspirin

Aspirin acetylates COX-1, blocking platelet thromboxane production.

• COX-1: Target enzyme (platelet-specific)
• 81–150mg: Typical dose (placeholder range)
• Platelet life: Effect duration (~7–10 days)
• Relatively spared: Prostacyclin (endothelial COX-2)

Selective platelet inhibition

Short placeholder: low dose favors TXA2 suppression over prostacyclin loss.

Placental Vasodilation and Perfusion Improvement

Balance shift toward prostacyclin widens placental vessels.

• Vasodilation: Vessel effect (placeholder summary)
• Improved: Perfusion (placeholder summary)
• ↑: Placental blood flow (placeholder trend)
• ↓: Preeclampsia risk (placeholder trend)

From molecular shift to perfusion

Short placeholder: reduced vasoconstriction supports healthier placental blood flow.

Continuing Aspirin Through Delivery

Daily dosing typically continues into late pregnancy for sustained effect.

• ~36 wks: Stop point (placeholder guideline)
• Daily: Adherence (placeholder requirement)
• Low: Bleeding risk (placeholder note)
• Unaffected: Delivery timing (placeholder note)

Sustained prophylaxis

Short placeholder: continuation maintains suppression until delivery.

Short placeholder: consistent daily dosing sustains protective effect.