🩸 Primary vs Secondary Amenorrhea Diagnostic Pathway Simulator

Primary vs Secondary — the First Branch in the Amenorrhea Algorithm

Placeholder: classification splits workup into congenital versus acquired pathways.

• Age 15: Primary defined by (Placeholder threshold note)
• 3+ months: Secondary defined by (Placeholder cycle gap)
• ~0.1%: Prevalence primary (Placeholder stat)
• ~3-4%: Prevalence secondary (Placeholder stat)

Initial classification step

Placeholder text describing the first branch decision.

Congenital Anatomy and Genetic Screening for Primary Amenorrhea

Placeholder: pelvic imaging and karyotype rule out anatomic and genetic causes.

• Step 1: Pelvic ultrasound (Placeholder note)
• If needed: Karyotype (Placeholder note)
• ~15%: Mullerian anomaly (Placeholder stat)
• ~5%: Turner syndrome (Placeholder stat)

Congenital checklist items

Placeholder text on imaging and karyotype workup order.

Hypothalamic Suppression — Stress, Weight, and Exercise in Secondary Amenorrhea

Placeholder: functional hypothalamic amenorrhea from energy deficit or stress.

• <18.5: Low BMI cutoff (Placeholder note)
• ~35%: FHA share of cases (Placeholder stat)
• Common: Exercise-linked (Placeholder note)
• Often yes: Reversible (Placeholder note)

Lifestyle and stress checklist

Placeholder text on weight, exercise, and stress history intake.

Hormone Panel Screening Across Both Diagnostic Branches

Placeholder: TSH, prolactin, FSH, and androgens screen for endocrine causes.

• Thyroid: TSH (Placeholder note)
• Pituitary: Prolactin (Placeholder note)
• Ovarian: FSH/LH (Placeholder note)
• ~30%: PCOS share (Placeholder stat)

Endocrine panel checklist

Placeholder text describing hormone panel interpretation.

Converging on a Diagnostic Conclusion and Next Steps

Placeholder: findings combine into a final recommended pathway.

• Refer genetics: Congenital path (Placeholder note)
• Lifestyle/endocrine tx: Acquired path (Placeholder note)
• MRI/US: Imaging confirm (Placeholder note)
• 3-6 months: Follow-up (Placeholder note)

Final pathway summary

Placeholder text on concluding the diagnostic algorithm.

Placeholder key insight sentence for stage five conclusion.