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Protein Conformational Search: 2D HP-Lattice Monte Carlo

2D companion to the 3D protein-folding lab: a polypeptide is reduced to a self-avoiding walk on a square lattice (Dill's HP model) and searched with pivot-move Metropolis Monte Carlo — tune temperature, hydrophobic strength and a chaperone bias and watch the energy landscape get explored live.

Molecular Biology2DModerate60 FPS📱 Mobile-adapted⇄ 3D version

Details

CategoryMolecular Biology

RenderingCanvas 2D

DifficultyModerate

Target FPS60

ControlsSliders for temperature, hydrophobic effect strength, chaperone bias and search speed; Reset & unfold, Pause and New sequence buttons; live move count, current energy, best energy found and acceptance-rate readouts.

protein foldinghp lattice modelmonte carlometropolis algorithmconformational searchenergy landscape

Related simulations

Protein Conformational Search3D molecular-dynamics view of a polypeptide chain finding its native fold.

Protein Folding Funnel LandscapeVisualizes the energy funnel that guides folding toward the native state.

Globular Protein Hydrophobic Collapse FoldingExplores the hydrophobic collapse that drives compact globular folds. ⊞ All 617 in Molecular Biology →

This 2D companion trades the 3D version's continuous molecular-dynamics chain for a coarse-grained lattice model that makes the conformational search itself legible: a 20-residue hydrophobic/polar sequence walks a square grid, a pivot-move Metropolis algorithm proposes rotations and accepts or rejects them from a live Boltzmann test, and a side panel exposes temperature, hydrophobic strength, a chaperone-style bias term and search speed alongside a running readout of the current, best-found and accepted-move statistics — plus an energy-history strip so you can watch the search anneal toward a compact hydrophobic core instead of just seeing the end state.

⚙ Under the hood

2D HP-lattice protein model with pivot-move Metropolis Monte Carlo, a live energy-history chart and a rolling acceptance-rate readout, showing the conformational search converging toward a compact hydrophobic core in real time.

protein foldinghp lattice modelmonte carlometropolis algorithmconformational searchenergy landscape

2D · HTML5 Canvas 2D · 60 FPS target · runs fully client-side, no install