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Microencapsulated Probiotic GI Delivery Simulator

Interactive 3D simulator: engineered probiotic capsules travel through a modeled GI tract, their enteric shell dissolving by local pH while bacterial viability decays under acid exposure — tune shell thickness, coating trigger pH, transit time and strain acid-tolerance to see what delivers a viable dose to the colon.

Microbiome & Metabolic Engineering3DModerate60 FPS

Delivering an engineered microbiome therapeutic to the gut is not just a biology problem — it's an encapsulation-engineering problem. This simulator sends a cohort of pH-responsive microcapsules along a modeled gastrointestinal tract, dissolving each capsule's enteric shell only once the surrounding pH crosses a tunable trigger, while the bacteria inside decay in viability at very different rates depending on whether the shell still shields them. Adjust shell thickness, coating trigger pH, total transit time and the strain's own acid tolerance to see how each design choice trades protection against a wasted, never-released dose — with live readouts of shell integrity, mean viability, and the fraction of the cohort actually delivering a viable dose to the colon.

⚙ Under the hood

Send a cohort of pH-responsive microcapsules carrying an engineered probiotic strain through a modeled GI tract, tuning shell thickness, enteric coating trigger pH, transit time and strain acid-tolerance to see how much viable dose actually survives to the colon.

microbiomedrug-deliveryencapsulationsynthetic-biologygut-physiologyprobiotics

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install