🌸 Menopausal Hormone Therapy Risk-Benefit Simulator

Vasomotor Symptom Relief With Hormone Therapy

Placeholder: HRT is the most effective treatment for hot flashes.

• ~75%: Hot flash reduction (placeholder figure)
• Improved: Sleep quality (placeholder figure)
• High: Genitourinary relief (placeholder figure)
• 2–4 wks: Onset of effect (placeholder figure)

Mechanism of symptomatic benefit

Placeholder: estrogen stabilizes thermoregulatory center function.

The Timing Hypothesis — Cardiovascular Risk Window

Placeholder: CV risk-benefit shifts with years since menopause onset.

• Favorable: Window <10 yrs (placeholder figure)
• Cautionary: Window >10 yrs (placeholder figure)
• Transdermal lower: Route effect (placeholder figure)
• Age-stratified: WHI reanalysis (placeholder figure)

Timing hypothesis mechanism

Placeholder: early initiation favors vascular health outcomes.

Breast Cancer Risk Considerations by Regimen

Placeholder: combined therapy carries different risk than estrogen-alone.

• Lower risk: Estrogen-alone (placeholder figure)
• Modest increase: Combined EPT (placeholder figure)
• Risk rises w/ time: Duration effect (placeholder figure)
• Declines after stop: Risk reversibility (placeholder figure)

Regimen-dependent risk profile

Placeholder: progestin component modifies breast cancer risk.

Bone Mineral Density Protection and Fracture Reduction

Placeholder: HRT preserves bone density and lowers fracture risk.

• Reduced: Hip fracture (placeholder figure)
• Reduced: Vertebral fracture (placeholder figure)
• Preserved: BMD change (placeholder figure)
• While on therapy: Effect duration (placeholder figure)

Skeletal protective mechanism

Placeholder: estrogen suppresses osteoclast-mediated bone resorption.

Shared Decision-Making for Individualized HRT Use

Placeholder: decisions weigh symptoms, age, and personal risk factors.

• Age at start: Key factor (placeholder figure)
• Baseline risk: Key factor (placeholder figure)
• Symptom severity: Key factor (placeholder figure)
• Annual: Review interval (placeholder figure)

Balancing individual risk and benefit

Placeholder: shared decision-making integrates all risk-benefit inputs.

Placeholder: individualized risk-benefit assessment guides HRT decisions.