HomeMedicine & BiophysicsOuter Hair Cell Electromotility & the Cochlear Amplifier

Outer Hair Cell Electromotility & the Cochlear Amplifier

Interactive 3D model of prestin-driven outer hair cell electromotility: watch the RC-filtered receptor potential drive somatic length changes that amplify basilar membrane vibration, and see the amplifier roll off at high frequency.

Medicine & Biophysics3DAdvanced60 FPS📱 Mobile-adapted⇄ 2D version
outer-hair-cell-electromotility-cochlear-amplification ↗ Open standalone

Outer hair cells (OHCs) do something no other mammalian cell does: their lateral-wall motor protein, prestin, changes the cell's own length tens of thousands of times per second, in step with sound. This simulator renders a local patch of the organ of Corti — a row of OHCs sitting between the basilar and tectorial membranes — and drives each cell's receptor potential through a real RC low-pass filter before feeding it into a prestin length-change model. The resulting electromotile force is fed back into the basilar membrane's vibration, visually reproducing the cochlear amplifier's boost in gain and its well-known rolloff once the stimulus frequency climbs past the membrane's own RC corner frequency. Live readouts track the filtered receptor potential, the cell's contraction amplitude in nanometers, and the resulting amplification in decibels relative to a passive (non-motile) cochlea.

⚙ Under the hood

Interactive 3D model of prestin-driven outer hair cell electromotility: an RC-filtered receptor potential drives somatic length changes that feed back into basilar membrane vibration, amplifying it until the stimulus frequency climbs past the membrane's own RC corner and the amplifier rolls off.

cochleahair cellprestinhearingelectromotilitybiophysics

3D · Three.js / WebGL renderer · 60 FPS target · runs fully client-side, no install

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