Reversible vs Irreversible Ischemic Cell Injury (2D)

This is the 2D companion to the 3D ischemic cell injury simulator, driven by the exact same per-cell ATP budget rather than a flattened render of the 3D scene: ischemia shuts off oxidative phosphorylation, ATP decays, the Na⁺/K⁺ pump fails, and osmotic water influx swells each cell — classic reversible cellular injury, drawn here as a flat, pannable, zoomable field of circles you can inspect one cell at a time. Each cell also accumulates an injury clock while its ATP stays critically low; cross that threshold and the mitochondrial permeability transition pore opens, marking the cell irreversibly injured no matter what happens next. Reperfusion — restoring blood flow mid-simulation — fully rescues any cell still on the reversible side of that line, while cells that already crossed it continue toward necrosis regardless, visualizing why the clinical treatment window in ischemic injury is a race against a real, cell-by-cell point of no return.